Endocrine Abstracts

CaSR-autoantibodies may cause auto-immune hypercalcemia through either simple blocking or biased properties. The phenotype of this rare disease is most often acquired hypocalciuric hypercalcemia (AAH) (Minanbres JCEM 2020, Makita JCI insight 2022), but sometimes hyperparathyroidism (Pelletier-Morel Intern Med 2008), in elderly. Gender, auto-immune context is variable. Blood calcium may fluctuate, and acute exacerbations may be successfully treated with predni...

Adipsic hypernatremia, a rare hypothalamic disorder characterized by a loss of thirst in response to hypernatremia is more often reported in children. An autoimmune mechanism has been recently demonstrated. We report two cases.Case1: A lean 67-year-old female, with a history of multilocular sclerosis, was admitted, for severe hypernatremia (162 mmol/l) with low ADH level (0.5 pmol/l; N: 0.5-2). She did not complain of thirst, despite ideomotor slowing an...

Familial Partial Lipodystrophy Syndromes (FPLD) are rare diseases characterized by partial lack of subcutaneous fat resulting in a severe metabolic syndrome and cardiovascular complications. Besides premature cell senescence, 2 main mechanisms are involved in FPLD: impaired adipocyte differentiation and lipid droplet, corresponding to two of the main causes of FPLD: LMNA-related FPLD2 and PLIN-related FPLD4. The objective of this study was to compare the clin...

Introduction: Guidelines recommend using first-line tests, including 24-hour urine-free cortisol (UFC), overnight 1-mg dexamethasone suppression test (DST), and late-night salivary cortisol (LNSC) for the positive diagnosis of hypercortisolism. Unfortunately, LNSC access is constrained in certain institutions, requiring, as an alternative, hospitalization for midnight plasmatic cortisol (F00h) measurement. This study explores the diagnostic potential of afternoon plasma cortis...